Verdezyne granted patent for engineered yeast, class of enzymes

By Kris Bevill | January 19, 2012

California-based biotechnology developer Verdezyne Inc. has been granted a U.S. patent titled “Engineered Microorganisms With Enhanced Fermentation Activity” for an engineered yeast and class of enzymes it developed, which can be used to ferment hard-to-process xylose found in cellulosic feedstocks.

According to Steven Picataggio, chief scientific officer at Verdezyne, xylose is the most abundant pentose sugar and can comprise up to 40 percent of cellulosic feedstocks under consideration for biofuels and biochemical production. “Unfortunately, yeast is naturally unable to ferment this xylose, and robust xylose fermentation remains a key bottleneck for commercializing the next-generation cellulosic ethanol process,” he said. It was with that bottleneck in mind that Verdezyne developed its newly patented class of unique enzymes, which enable the yeast to ferment xylose at high yields under anaerobic conditions.

Verdezyne is a privately held company focused on developing fermentation processes for renewable fuels and chemicals. Its investors include BP Alternative Energy Ventures, DSM Venturing B.V., Monitor Ventures and OVP Venture Partners. Late last year Verdezyne opened a pilot plant in Carlsbad, Calif., to commercialize its biobased adipic acid production process.

The company has also previously collaborated with Milwaukee, Wis.-based Lallemand Ethanol Technology to develop genetically enhanced high-yielding yeast for first-generation ethanol production.

The company has not yet inked a deal with potential cellulosic ethanol producers to use its patented enzymes, but Picataggio said a number of ethanol and biobased chemical companies have expressed interest in them. “The company is in late-stage discussions with potential cellulosic ethanol producers to use our patented technology,” he added.